TIL that men and women process physical pain differently.

Read more: https://www.eurekalert.org/news-releases/947138

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  1. >A new study published in the journal BRAIN shows for the first time that neurons in the spinal cord process pain signals differently in women compared to men. The finding could lead to better and more personalized treatments for chronic pain, which are desperately needed, especially in light of the opioid epidemic.
    >Although it has long been known that women and men experience pain differently, most pain research uses male rodents. The new study is unique because it used female and male spinal cord tissue from both rats and humans (generously donated by deceased individuals and their families).
    >By examining the spinal cord tissue in the laboratory, the researchers were able to show that a neuronal growth factor called BDNF plays a major role in amplifying spinal cord pain signaling in male humans and male rats, but not in female humans or female rats. When female rats had their ovaries removed, the difference disappeared, pointing to a hormonal connection.
    >This is the first time a sex-related difference in pain signaling has been identified in human spinal cord tissue. Future studies are required to understand how this biological difference may contribute to differences in pain sensation between men and women.

    Full academic journal study: [https://academic.oup.com/brain/article/145/3/1124/6551129](https://academic.oup.com/brain/article/145/3/1124/6551129)

    >In quantitative evaluation of experimentally induced pain in humans, women show more pain sensitivity than men across several noxious modalities, including mechanical-, electrical-, thermal- and chemical-induced pain. Given these epidemiological and clinical sex differences and the rising health crisis of poorly managed chronic pain, it is essential to systematically investigate the neurobiological underpinnings of pain processing in both sexes. Unfortunately, the vast majority of foundational preclinical pain research has been conducted in male rodents only.

  2. I’ll tell that my wife. When we’re both sick, she can still force herself to do things that i literally cannot do at that moment. Then i receive “man flu” jokes from all females around

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