TIL that the surgeon August Bier tested on his own assistant a form of anesthesia consisting of injecting cocaine directly into the spine, and to check how effective it was, he stuck a needle in his leg, hit him in the shins with a hammer, ripped off his pubic hair and even squeezed his testicles.

Read more: https://en.wikipedia.org/wiki/August_Bier#Spinal_anesthesia

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